Programme de bourses "Echanges Universitaires"

The docking step of salmonella host cell infection

Salmonella is a rod-shaped, gram-negative food borne pathogen known to cause a wide variety of diseases ranging from mild diarrhea to severe systemic infections like typhoid fever in humans. Salmonella virulence is based on genes located in Salmonella pathogenicity islands (SPI-1 and SPI-2.  Invasion into host cells is an important step of Salmonella pathogenesis. Binding to the host cell surface is thought to be an essential step in this process. However, it is still poorly understood. I have employed image based high throughput assays in order to analyze bacterial and host cell determinants required for efficient pathogen docking to the host cell. This work identified the SPI-1 type III secretion system and several other bacterial factors. These results improve our understanding of the infection process and may point out drug targets that might be of value for the design of anti-infective therapeutics.

Samuel Rout

Wolf-Dietrich Hardt and Mrutyunjay Suar

Addresses:

Samuel Rout
59-Madhusudan Nagar
751001 Bhubaneswar
India

Prof. Dr. Mrutyunjay Suar
KIIT School of Biotechnology
Patia Street
751024 Bhubaneswar
India

Prof. Dr. Wolf-Dietrich Hardt
Inst. of. Microbiology
ETH Zürich
Wolfgang-Paulistr. 10
8093 Zürich
Switzerland